文章基本信息

标题：METABOLISM OF PHTHALIDYL THEOPHYLLINE IN RAT LIVER
本地全文：下载
作者：KANYA TONDA ; MASAHARU HIRATA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：1
页码：15-20
DOI：10.1248/bpb1978.10.15
出版社：The Pharmaceutical Society of Japan
摘要：Phthalidyl theophylline (PH-TH) in rat liver was metabolized by a hydrolase to theophylline (TH) and 2-carboxybenzaldehyde, and the latter was further metabolized to 2-hydroxymethylbenzoic acid by an nicotinamide adenine dinucleotide-dependent reductase. The hydrolase could be strongly inhibited by acetazolamide, therefore, urinary excretion of PH-TH metabolites was significantly retarded when PH-TH and acetazolamide were coadministered to rats. The results from in vivo experiments suggest that PH-TH was efficiently absorbed from the gastrointestines and metabolized extensively by the liver.
关键词：acetazolamide inhibition.