文章基本信息

标题：SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
本地全文：下载
作者：AKIHIDE KODA ; NAOKI INAGAKI ; NOBUO TSURUOKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：2
页码：104-111
DOI：10.1248/bpb1978.10.104
出版社：The Pharmaceutical Society of Japan
摘要：Mite dialysate prepared from an extract of house dust mite, Dermatophagoides farinae, suppressed 48-h homologous passive cutaneous anaphylaxis (PCA) in rats caused by a non-dialyzable fraction of the mite extract (mite antigen), and the suppression was dosedependent with a high specificity for the antigen. The mite dialysate itself slightly elicited the PCA. Fraction 3 obtained from the mite dialysate by means of DEAE-Sephadex A-25 column chromatography suppressed PCA in rats and guinea pigs more potently than mite dialysate. Histamine release from sensitized rat peritoneal exudate cells (PEC) induced by the mite antigen was suppressed in a dose-dependent manner when the PEC had been previously incubated with fraction 3. However, incubation of the PEC with fraction 3 caused a significant release of histamine compared to the spontaneous value. Fraction 3 clearly inhibited the passive hemagglutination of the mite antigen-conjugated sheep red blood cells caused by rat hyperimmunized serum. From these results it was considered that certain haptenic substances might be present in the mite dialysate.
关键词：antigen-antibody reaction