文章基本信息

标题：Involvement of the Medial Amygdaloid Nucleus in the Action of Imipramine in Rats Subjected to the Forced Swimming Test
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作者：Takao SHIMAZOE ; Shigenobu SHIBATA ; Shinichi YATSUGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1988
卷号：11
期号：2
页码：137-139
DOI：10.1248/bpb1978.11.137
出版社：The Pharmaceutical Society of Japan
摘要：A forced swimming test proposed by Porsolt is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala lesioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.
关键词：vibration