文章基本信息

标题：Pharmacokinetics of Two Rectal Dosage Forms of Ketoprofen in Patients after Anal Surgery
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作者：Ikuo KANAMOTO ; Teruaki NAKAGAWA ; Isamu HORIKOSHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1988
卷号：11
期号：3
页码：141-145
DOI：10.1248/bpb1978.11.141
出版社：The Pharmaceutical Society of Japan
摘要：Two kinds of dosage forms of commercially available suppositories containing ketoprofen (KP), fatty suppositories (FS) and gelatin capsulated suppositories (GCS), were administered to patients immediately after anal surgery, and results obtained were compared. No difference was found in each corresponding pharmacokinetic parameter of the two dosage forms. However, when these parameters were compared with those from healthy subjects, significant differences were found in the values of peak level (C_max), peak time (T_max) and terminal phase half-life (t_1/2). C_max decreased by one half, and T_max and t_1/2 increased two and four times longer, respectively, those from healthy subjects. The absorption rate constant (k_a) in patients was significantly (p < 0.01) smaller than that in healthy subjects. However, the distribution volume/bioavailability (V_d/F), elimination rate constant (k_el), and area under the curve (AUC) differed only slightly. Consequently, the flip-flop phenomena could be seen in the time profiles of plasma KP concentration of patients. These results suggested that the rectal suppository of KP should be administered with care, especially in the patients operated on under spinal anesthesia.
关键词：patient