文章基本信息

标题：Reduction of Cyclophosphamide-Induced Toxicity by Diethyldithiocarbamate and Carbon Disulfide and Its Possible Mechanism
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作者：Shinobu FURUSAWA ; Kenichi SASAKI ; Giichi TAKAYANAGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1988
卷号：11
期号：4
页码：284-287
DOI：10.1248/bpb1978.11.284
出版社：The Pharmaceutical Society of Japan
摘要：The mechanism of reduction in cyclophosphamide (CPA)-induced toxicity by diethyldithiocarbamate (DTC) and carbon disulfide (CS₂) was examined in relation to CPA metabolism in mice. Pretreatment with DTC (100 mg/kg) or CS₂ (50 mg/kg), p. o. decreased the acute toxicity of CPA. Active metabolites of CPA in the plasma after the administration of CPA (100 or 450 mg/kg, i. p.) was lowered by DTC or CS₂ treatment. The liver microsomal CPA oxidase activity decreased 1 h after the administration of DTC (25-100 mg/kg, p. o.) or CS₂ (12.5-50 mg/kg, p. o.). These results suggested that the reduction of CPA-induced toxicity in mice pretreated with DTC or CS₂ was due to the inhibition of activation of CPA and reduced formation of alkylating metabolites.
关键词：cyclophosphamide oxidase