文章基本信息

标题：Effect of CV-3988, a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
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作者：Naoki INAGAKI ; Toru MIURA ; Kenji OHIRA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1990
卷号：13
期号：5
页码：272-277
DOI：10.1248/bpb1978.13.272
出版社：The Pharmaceutical Society of Japan
摘要：Effect of CV-3988, a specific antagonist against platelet activating factor (PAF), on homologous passive cutaneous anaphylaxis (PCA) elicited in the mouse ear was investigated. PAF caused a potent increase in vascular permeability in the mouse ear. The potency was slightly lower than that of serotonin but higher than those of histamine, leukotriene (LT) C₄, LTD₄, prostaglandin (PG) E₁ and PGE₂ on a weight basis. The increased vascular permeability caused by PAF was inhibited by CV-3988 in a dose-dependent manner. CV-3988 did not affect the increase in vasular permeability caused by histamine or serotonin. IgG1 antibody-mediated PCA in the mouse ear was inhibited by CV-3988, although it did not affect IgE antibody-mediated PCA. These results suggest a possibility that PAF might be involved in IgG1 antibody-mediated PCA in the mouse.
关键词：passive cutaneous anaphylaxis (PCA)