文章基本信息

标题：PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
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作者：Shogo TOKUYAMA ; Masakatsu TAKAHASHI ; Hiroshi KANETO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1991
卷号：14
期号：6
页码：357-361
DOI：10.1248/bpb1978.14.357
出版社：The Pharmaceutical Society of Japan
摘要：In mice, both swimming-stress induced analgesia (SW-SIA) and clonidine (CLO) analgesia were dose dependently antagonized by yohimbine, an α2-adrenoceptor antagonist, but not by naloxone, an opioid μ-antagonist. SW-SIA was potentiated by subanalgesic dose of CLO, and CLO analgesia was enhanced by SW-SIA. Animals tolerant to CLO analgesia were tolerant to SW-SIA, in contrast, CLO analgesia was potentiated in SW-SIA tolerant mice. Thus, SW-SIA and CLO analgesia partially share a common α2-adrenergic-dependent mechanism, for their production.
关键词：α2-adrenoceptor