文章基本信息

标题：Changes in Ingestive Behavior Induced by Intracranial Injection of Spermine
本地全文：下载
作者：Hiroyuki KOHNO ; Tsukasa SAKURADA ; Kensuke KISARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1991
卷号：14
期号：7
页码：407-412
DOI：10.1248/bpb1978.14.407
出版社：The Pharmaceutical Society of Japan
摘要：Effect of intracranial injection of spermine on feeding and drinking behavior was studied in rats. A significant and long-term suppression of feeding and drinking behavior appeared when 30 nmol/hemisphere of spermine was bilaterally injected into the lateral hypothalamic area, substantia nigra or ventral noradrenergic bundle. Micro-injected spermine into the medial amygdaloid nucleus produced a weak and short-time but significant suppression of ingestive behavior. On the other hand, a significant increase in feeding and drinking behavior was observed when spermine was injected into the ventromedial hypothalamic nucleus. These results suggest that spermine inhibits neuronal activity of all the brain regions studied here.
关键词：ventral noradrenergic bundle