文章基本信息

标题：The Effects of Adenine and Dimethyl Sulfoxide on the Mouse Pancreas
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作者：Yuko OKAZAKI ; Takeshi MINAMI ; Kensuke NATSUI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1992
卷号：15
期号：11
页码：605-610
DOI：10.1248/bpb1978.15.605
出版社：The Pharmaceutical Society of Japan
摘要：The authors have studied the effects of dimethyl sulfoxide (DMSO) on the plasma α-amylase activity in mice that sustained a pancreatic injury induced by an oral administration of adenine. In mice given a 5% solution of DMSO as drinking water for 3 d prior to the administration of adenine (175 mg/kg), and also drank this DMSO solution until the end of the experiment, hyperemia of the pancreas was observed and the level of plasma α-amylase activity became significantly higher than the level seen in the control mice. A pathological examination also revealed vacuolation and zymogenic degranulation. Further, the plasma α-amylase activity level increased only in mice given this 5% DMSO solution, and no increase was noted in mice given a 3% or a 1% DMSO solution for drinking water. Further, the pancreatic lipid peroxide level of mice given this 5% DMSO solution was significantly higher than the level seen in the control group. Based on the above results and associated data, it is thought that an oral administration of adenine can induce a pancreatic injury in the mouse, and that this injury is sustained with the assistance of DMSO.
关键词：lipid peroxide