文章基本信息

标题：EFFECT OF COLCHICINE AND CYTOCHALASIN B ON THE SECRETION OF PROTEOCHONDROITIN SULFATE AND PROTEINFREE CHONDROITIN SULFATE SYNTHESIZED IN CARTILAGE SLICES
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作者：ATSUSHI HONDA ; FUMIE TAKAKUBO ; NAOTO MURAKAMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：5
页码：327-330
DOI：10.1248/bpb1978.2.327
出版社：The Pharmaceutical Society of Japan
摘要：A possible role of microtubules and microfilaments in the secretion process of proteoglycan and protein-free glycosaminoglycan synthesized in slices of bovine nasal cartilage was examined by using colchicine as an antimicrotubular agent, cytochalasin B as a microfilament-modifying agent, and 4-methylumbelliferyl β-D-xyloside as an artificial initiator of glycosaminoglycan. The present study suggested that the microtubule system was partly involved in the secretion of proteochondroitin sultate and protein-tree chondroitin sultate synthesized in chondrocytes. The microfilament system did not have any direct effect on this secretion process.
关键词：bovine nasal cartilage