文章基本信息

标题：6-HYDRXYDOPA-INDUCED STIMULATION OF ORNITHINE DECARBOXYLASE ACTIVITY IN THE DEVELOPING RAT BRAIN
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作者：YASUYUKI NOMURA ; YASUNOBU OKUMA ; TOMIO SEGAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：5
页码：306-308
DOI：10.1248/bpb1978.2.306
出版社：The Pharmaceutical Society of Japan
摘要：The developmental alteration in the specific activity of ornithine decarboxylase (ODC) was investigated in the brain of rats treated with 6-hydroxydopa (6-OHDOPA) at birth. The specific activity of ODC in the cerebral hemispheres, brain stem and cerebellum declined from high level on day 4 to the non-detectable level in the adult. The neonatal treatment with 6-OHDOPA (75 mg/kg, s. c., 3 days) produced the rapid increase of ODC activity in the cerebral hemispheres and the brain stem in the 4- and 5-day-old rat. An injection of 6-OHDOPA appears to affect cellular activity of catecholamine neurons and glial cells in the developing brain.
关键词：cellular activity