文章基本信息

标题：COMPARISON OF EFFECTS OF EXTERNAL Ca2+ ON ANTIOXYTOCIN ACTIONS OF ANTISPASMODICS IN OVARIECTOMIZED AND ESTRADIOL-TREATED RAT UTERI
本地全文：下载
作者：TSUTOMU URUNO ; KEIICHI TABATA ; MINAKO SUZUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：8
页码：380-389
DOI：10.1248/bpb1978.3.380
出版社：The Pharmaceutical Society of Japan
摘要：The influence of Ca²⁺ on the antioxytocin actions of papaverine, deoxycholate and 1, 1-diphenyl-3-piperidinobutanol hydrochloride (Aspaminol) was investigated in the ovariectomized and the estradiol-treated rat uteri, and Ca exchangeability and Ca content in both uteri were compared. No qualitative difference in the responses to deoxycholate and Aspaminol at normal and higher Ca²⁺ concentrations in the estradiol-treated rat uterus was seen as compared to those obtained from the ovariectomized one. The antioxytocin action of papaverine in the estrogenized uterus was antagonized by excess external Ca²⁺, but not in the ovariectomized one. There were no significant differences either in the total Ca content or the non-displaceable Ca by La between the ovariectomized and the estrogenized rat uterine longitudinal muscle layers, while Ca exchangeability in the estrogenized specimen was much greater than that in the ovariectomized one. These results suggest that the antagonism of papaverine against excess exogenous Ca²⁺ may be related to the more increased Ca exchangeability in the estradiol-treated rat myometrium.
关键词：Ca exchangeability