文章基本信息

标题：ROLE OF ADRENERGIC AGONISTS ON GASTRIC SECRETION IN THE RAT
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作者：SATORU TANI ; NORIO MUTO ; NATSUKO KAWATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：10
页码：507-513
DOI：10.1248/bpb1978.3.507
出版社：The Pharmaceutical Society of Japan
摘要：Following previous demonstration that isoproterenol stimulated and norepinephrine inhibited gastric acid secretion induced by secretagogues, role of adrenergic agonists was studied by measuring acidity and peptic activity of the effluent of the perfused rat stomach. Response of gastric secretion to isoproterenol was increased by theophylline treatment but was not affected by metiamide treatment. N⁶, O^2'-Dibutyryladenosine 3', 5'-cyclic monophosphoric acid sodium salt monohydride (dibutyryl-c-AMP) stimulated gastric secretion in a dose-dependent manner. These results suggest the possibility that the action of isoproterenol in gastric acid secretion is mediated by c-AMP. However, gastric secretion induced by pentagastrin, histamine, or carbamylcholine was not affected by theophylline treatment. N², O^2'-Dibutyrylguanosine 3', 5'-cyclic monophosphoric acid sodium salt (dibutyryl-c-GMP) did not exert any effect on gastric secretion. Depression of pentagastrin-induced gastric secretion by norepinephrine was reversed by EGTA infusion. Moreover, Ca²⁺ depressed pentagastrininduced gastric secretion. These results suggest that the action of norepinephrine is closely related to the concentration of Ca²⁺.
关键词：EGTA