文章基本信息

标题：MUTAGENICITY OF N-ACYLGLYCINOHYDROXAMIC ACIDS AND RELATED COMPOUNDS
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作者：KEIICHI MUNAKATA ; HISATOSHI MOCHIDA ; SENJI KONDO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：11
页码：557-561
DOI：10.1248/bpb1978.3.557
出版社：The Pharmaceutical Society of Japan
摘要：The mutagenic activity of twenty-nine new N-acylglycinohydroxamic acids and related compounds was tested on Bacillus subtilis (Rec⁺, Rec^-) and Salmonella typhimurium (TA 98, TA 100). All the N-(substituted-benzoyl) glycinohydroxamic acids, except 3-acetylaminobenzoyl-derivative, were shown to be mutagenic to both test bacteria, whereas most of the N-aliphatic acylglycinohydroxamic acids were found to be non-mutagenic. In the present study, we discussed our observations focussing on the structure-activity correlation between their chemical structures and mutagenic activities.
关键词：structure-activity correlation