文章基本信息

标题：METABOLISM OF ISONIAZID AND FREE HYDRAZINE FORMATION IN ISOLATED RAT HEPATOCYTES
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作者：MASAHARU HIRATA ; YOSHINORI ASO ; KUANGYANG HSU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：2
页码：145-147
DOI：10.1248/bpb1978.4.145
出版社：The Pharmaceutical Society of Japan
摘要：Isoniazid (INH) was incubated with isolated rat hepatocytes, and the amounts of acetyl-INH, monoacetylhydrazine, diacetylhydrazine and hydrazine formed were determined by gas chromatography-mass spectrometry (GC-MS). Subsequent analyses of kinetic parameters of metabolic pathways and enzymological study of rat liver homogenate revealed that hydrazine was formed preferentially from INH, catalized by soluble hydrolytic enzymes.
关键词：mass fragmentography