文章基本信息

标题：PROTECTIVE EFFECTS OF CYCLODEXTRINS ON DRUG-INDUCED HEMOLYSIS IN VITRO
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作者：KANETO UEKAMA ; TETSUMI IRIE ; MIKI SUNADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：2
页码：142-144
DOI：10.1248/bpb1978.4.142
出版社：The Pharmaceutical Society of Japan
摘要：β-Cyclodextrin (β-CyD) significantly protected the human erythrocytes from hemolysis and shape changes induced with chlorpromazine and flufenamic acid in isotonic solution. A good correlation between the stability constants of inclusion complexes (β->γ->α-CyD) and the inhibitory effects on drug-induced hemolysis was found. From the observations of drug uptake into erythrocytes and changes in surface tension, the protective effects of CyDs appeared to be due to the decrease in effective concentration of drug through inclusion complexation rather than the direct interaction of CyDs with erythrocyte membrane.
关键词：surface tension