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标题：INCREASED UPTAKE OF 5-FLUOROURACIL BY EHRLICH ASCITES TUMOR CELLS WITH SOME ADDITIVES AND METABOLITE ANALYSIS
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作者：MASAKATSU TEZUKA ; YUJI CHIKARAISHI ; OSAMU TAMEMASA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：11
页码：893-899
DOI：10.1248/bpb1978.5.893
出版社：The Pharmaceutical Society of Japan
摘要：We studied the uptake of radioactive 5-fluorouracil (FUra) by the intact cells of Ehrlich ascites tumor in the presence of various coreactants with FUra such as uridine (Urd), deoxyuridine (dUrd), ribose 1-phosphate (Rib1P), and deoxyribose 1-phosphate (dRib1P). Radioactivity uptake by the cells was increased when FUra-6-¹⁴C was incubated with Rib1P of dRib1P, while the uptake was not stimulated with Urd or dUrd. The increased formation of antineoplastic ribo- and deoxyribo-nucleotides of FUra in the acid-soluble fraction was also observed in the same incubation with Rib1P or dRib1P. Also, some detergents, ethylenediaminetetraacetic acid (EDTA), adenosine 5'-triphosphate (ATP), and polymines were examined. EDTA stimulated the uptake of radioactivity from the FUra by the cells. However, the other compounds exhibited no effect on the uptake of FUra alone or FUra plus dRib1P, except of ATP showing somewhat increase of radioactivity uptake. The above results suggest that the coadministration of FUra together with Rib1p or/and dRib1P, which are stimulants for the formation of FUra-deoxynucleotides from FUra, may be able to potentiate the chemotherapeutic effect of FUra.
关键词：cancer chemotherapy with FUra