文章基本信息

标题：ENHANCEMENT OF ANTITUMOR ACTIVITY OF 5-FLUOROURACIL BY RIBOTHYMIDINE
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作者：MASAKATSU TEZUKA ; YOSHIYUKI CHIBA ; SHOJI OKADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1986
卷号：9
期号：8
页码：683-687
DOI：10.1248/bpb1978.9.683
出版社：The Pharmaceutical Society of Japan
摘要：The antitumor activity of 5-fluorouracil (5-FU) in combination with ribothymidine was examined on some experimental murine carcinomas. The antitumor activity of 5-FU against Ehrlich ascites carcinoma was markedly enhanced by intraperitoneal coadministration of ribothymidine. The enhancement of the antitumor activity of 5-FU by ribothymidine was also observed against Ehrlich solid carcinoma both by oral and intraperitoneal administrations. Furthermore, the combination therapy of 5-FU and ribothymidine was effective even on 5-FU-resistant P388 leukemia. These results suggest that the combination of 5-FU and ribothymidine may be more effective than 5-FU monotherapy in clinical use.
关键词：5-FU-resistant P388 leukemia