文章基本信息

标题：IN VITRO EFFECT OF CINNAMIC ALDEHYDE, A MAIN COMPONENT OF CINNAMOMI CORTEX, ON HUMAN PLATELET AGGREGATION AND ARACHIDONIC ACID METABOLISM
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作者：MITSUKO TAKENAGA ; AIZAN HIRAI ; TAKASHI TERANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：5
页码：201-208
DOI：10.1248/bpb1978.10.201
出版社：The Pharmaceutical Society of Japan
摘要：The in vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on platelet aggregation and arachidonic acid (AA) metabolism in human platelets was studied. Cinnamic aldehyde reduced platelet aggregation of both platelet rich plasma and washed platelets, dose-dependently. This compound also decreased the formation of the metabolites of AA such as thromboxane B₂ (TXB₂), 12-hydroxy heptadecatrienoic acid and 12-hydroxyeicosatetraenoic acid in collagen-stimulated washed platelets. The conversion of exogenous [¹⁴C] AA to cyclooxygenase metabolites or 12-lipoxygenase metabolite was not altered significantly by the addition of cinnamic aldehyde. On the other hand, collagen-induced released of [¹⁴C] AA and its metabolites from washed platelets prelabeled with [¹⁴C] AA was markedly reduced by the addition of cinnamic aldehyde. These results suggested that cinnamic aldehyde suppressed the release of AA from platelet membrane phospholipids and then reduced the formation of thromboxane A₂. This inhibitory effect of cinnamic aldehyde on AA release and TXB₂ formation may contribute to reduced platelet aggregation.
关键词：12-lipoxygenase