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标题：INTESTINAL ABSORPTION AND METABOLISM OF HOMOURSO DEOXYCHOLIC ACID IN RATS
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作者：TAIJU KURAMOTO ; SHIGERU MORIWAKI ; KEIKO KAWAMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：7
页码：309-316
DOI：10.1248/bpb1978.10.309
出版社：The Pharmaceutical Society of Japan
摘要：Intestinal absorption, hepatic biotransformation and intestinal bacterial modification of the C₂₅ homolog of ursodeoxycholic acid, homoursodeoxycholic acid, and its glycine conjugate, glycohomoursodeoxycholic acid, were studied in rats. Homoursodeoxycholic acid, like ursodeoxycholic acid, was efficiently absorbed from the intestine and rapidly excreted into the bile. Most (>95%) of the absorbed homoursodeoxycholic acid was found to undergo β-oxidation to form two C₂₃ bile acids, norursodeoxycholic acid and nor-β-muricholic acid during passage through the liver. Bacterial modification of homoursodeoxycholic acid was very similar to that of ursodeoxycholic acid. In the rat intestinal tract, glycohomoursodexycholic acid was deconjugated to form unconjugated homoursodeoxycholic acid which was then 7β-dehydroxylated to form homolithocholic acid.
关键词：bacterial modification