文章基本信息

标题：PROLONGATION OF LIFE SPAN OF DYSTROPHIC HAMSTER BY CYSTEINE PROTEINASE INHIBITOR, LOXISTATIN (EST)
本地全文：下载
作者：MASAHARU TAMAI ; SADAFUMI OMURA ; MASAAKI KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：11
页码：678-681
DOI：10.1248/bpb1978.10.678
出版社：The Pharmaceutical Society of Japan
摘要：We studied the effect of loxistation (EST), an orally applicable cysteine proteinase inhibitor, on dystrophic hamsters, UM-X7.1.E-64-c, an active form of EST, was continuously found in plasma when the feed containing EST was given ad libitum. The drug concentration in plasma of dystrophic hamsters receiving EST feed showed distinct dose dependency. A diet containing EST from weaning to death significantly prolonged the survival period of the dystrophic hamsters.
关键词：dystrophy