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标题：INTENSIFICATION OF HOST'S IMMUNITY BY SQUALENE IN SARCOMA 180 BEARING ICR MICE
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作者：TETSUO OHKUMA ; KENJI OTAGIRI ; SHIGEO TANAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：2
页码：148-151
DOI：10.1248/bpb1978.6.148
出版社：The Pharmaceutical Society of Japan
摘要：Effect of highly purified squalene (HP-SQ) obtained from liver of a shark, Centrophorus atromarginative GARMAN, on antitumor activity and host's immune response was studied in sarcoma 180 bearing female ICR mice. HP-SQ was administered intraperitoneally (i.p.) to solid tumor-bearing or healthy mice at the dose of 0.1ml/mouse/d for consecutive 10d. The administration of HP-SQ exerted the host's resistance against challenging 5×10⁴ cells of ascites sarcoma 180, and it resulted in marked prolongation of survival of the mice (ILS ; 110%). Function of the reticuloendothelial system estimated by a carbon clearance test was enhanced by i.p. administration of HP-SQ in both the healthy and the tumor-bearing mice. Number of IgM antibody forming cells against sheep red blood cells (SRBC) in the spleen was counted 4d after intravenous injection of 2×10⁷ cells of SRBC. The number of the IgM antibody forming cell increased by HP-SQ administration in the tumor-bearing and the healthy mice. Delayed hypersensitivity reaction against SRBC measuring swelling of the foot pads of mice was also stimulated by the i.p. administration of the material.
关键词：delayed hypersensitivity