文章基本信息

标题：EFFECT OF N-FORMYL-L-METHIONYL-L-LEUCYL-L-PHENYLALANINE AND ITS ANALOGUES ON BLOOD PRESSURE
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作者：HARUO SAITO ; MOTOYA MATSUO ; SHIGERU NAMINOHIRA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：2
页码：141-144
DOI：10.1248/bpb1978.6.141
出版社：The Pharmaceutical Society of Japan
摘要：Effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), the synthetic chemotactic peptide, and its analogues on blood pressure were investigated in the rabbit, rat, mouse, dog, cat and guinea pig. The administration of FMLP (5μg/kg i.v.) induced the depressor effect in the rabbit but no effect was observed in the other animal species. The only peptide which showed a similar effect as FMLP was N-formyl-L-methionyl-L-methionyl-L-phenylalanine (FMMP) among the peptides relating to FMLP. Tachyphylaxis was observed in the hypotensive action induced by the two peptides.
关键词：tachyphylaxis