文章基本信息

标题：IMPROVEMENT OF ORAL BIOAVAILABILITY OF PREDNISOLONE BY β-CYCLODEXTRIN COMPLEXATION IN HUMANS
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作者：KANETO UEKAMA ; MASAKI OTAGIRI ; YUJI UEMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：2
页码：124-127
DOI：10.1248/bpb1978.6.124
出版社：The Pharmaceutical Society of Japan
摘要：Inclusion complex of prednisolone with β-cyclodextrin (β-CyD) in 1 : 2 molar ratio was prepared and its dissolution, membrane permeation and oral absorption behaviors were examined. The rates of dissolution and permeation through a cellophane membrane in water were significantly increased by β-CyD complexation. A crossover bioavailability study was performed using human subjects with lower doses of prednisolone tablets, where the plasma levels of the drug were determined by radioimmunoassay. The enhanced bioavailability of prednisolone by β-CyD complexation suggested the possibility of smaller doses and fewer side effects in prednisolone therapy.
关键词：radioimmunoassay