文章基本信息

标题：AUGMENTATION OF HOST'S IMMUNITY BY COMBINED CRYODESTRUCTION OF SARCOMA 180 AND ADMINISTRATION OF PROTEIN-BOUND POLYSACCHARIDE, EA6, ISOLATED FROM FLAMMULINA VELUTIPES (CURT.ex FR.) SING.IN ICR MICE
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作者：TETSUO OHKUMA ; SHIGEO TANAKA ; TETSURO IKEKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：2
页码：88-95
DOI：10.1248/bpb1978.6.88
出版社：The Pharmaceutical Society of Japan
摘要：Augmentation of the host's immunity by combined in situ freeze-destruction of the tumor (cryosurgery) and administration of the antitumor active protein-bound polysaccharide, EA₆, isolated from a hot water extract of an edible mushroom, Flammulina velutipes (CURT.ex FR.) SING., was investigated in sarcoma 180 bearing ICR mice. Oral administration (p.o.)of the EA₆ stimulated anti-sheep red blood cells (SRBC) IgM antibody-producing activity of the spleen cells, and also delayed hypersensitivity (DTH) against SRBC in swelling of the foot pads of the tumor-bearing hosts. When EA₆ p.o. was combined with cryosurgery, further augmentation of IgM-producing activity and DTH reaction to SRBC was recognized as compared with the EA₆ single use. But the reticuloendothelial system of the mice, estimated by carbon clearance test, was not activated by EA₆ p.o. or combined with cryosurgery.
关键词：delayed hypersensitivity