文章基本信息

标题：RELATIONSHIP BETWEEN TRIMETHADIONE METABOLISM AND HEPATIC DRUG-OXIDIZING ENZYME ACTIVITIES IN DIFFERENT ANIMAL SPECIES
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作者：EINOSUKE TANAKA ; HARUKI KINOSHITA ; TAKEMI YOSHIDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：7
页码：481-486
DOI：10.1248/bpb1978.6.481
出版社：The Pharmaceutical Society of Japan
摘要：The purpose of this investigation is to correlate between trimethadione (TMO) metabolism and hepatic microsomal drug-oxidizing activities in different animal species (mouse, hamster, rat and rabbit). A good correlation was obtained between the plasma concentration ratio of 5, 5-dimethyl-2, 4-oxazolidinedione (DMO) to TMO and relative activities of aminopyrine (γ=0.999 at 1 h, p<0.01;γ=0.994 at 2 h, p<0.01) and TMO (γ=0.988 at 1 h, p<0.02;γ=0.975 at 2 h, p<0.05) N-demethylase, and aniline (γ=0.993 at 1 h, p<0.01;γ=0.979 at 2 h, p<0.01) hydroxylase. These results indicate that the values of plasma DMO/TMO ratio determined at an appropriate time period following its administration would be reflecting the degree of hepatic drug-oxidizing capacity in various experimental animal species. These findings thus suggest that in vivo TMO metabolism would be a useful drug for predicting hepatic drug-oxidizing capacity in humans.
关键词：different animal species