文章基本信息

标题：DECOMPOSITION OF HYDROPEROXIDES DERIVED FROM MICROSOMES OR LIPOPROTEIN BY GLUTATHIONE PEROXIDASE AND GLUTATHIONE S-TRANSFERASE
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作者：TOSHINOBU MIWA ; TETSUO ADACHI ; KAZUYUKI HIRANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：7
页码：459-465
DOI：10.1248/bpb1978.6.459
出版社：The Pharmaceutical Society of Japan
摘要：Protective effects of glutathione peroxidase, glutathione S-transferase purified from human liver and superoxide dismutase against lipid peroxidation were investigated. In the presence of glutathione, lipid hydroperoxides found in microsomal membrane were decomposed by glutathione peroxidase and cationic glutathione S-transferase, but anionic glutathione S-transferase had no effect on them. Superoxide dismutase exhibited antioxidation effect by preventing accumulation of lipid hydroperoxides. Serum lipid hydroperoxides existing in low density lipoprotein fraction were also decomposed by glutathione peroxidase and cationic glutathione S-transferase. These findings suggest that the hydroperoxide level, which has high toxicity, could be controlled by these glutathione-dependent glutathione peroxidase and cationic glutathione S-transferase.
关键词：lipoprotein