文章基本信息

标题：REDUCTION IN THE LOCAL TISSUE TOXICITY OF CHLORPROMAZINE BY β-CYCLODEXTRIN COMPLEXATION
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作者：TETSUMI IRIE ; SHINJI KUWAHARA ; MASAKI OTAGIRI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：10
页码：790-792
DOI：10.1248/bpb1978.6.790
出版社：The Pharmaceutical Society of Japan
摘要：Effect of β-cyclodextrin (β-CyD) on the local tissue toxicity of chlorpromazine (CPZ) was investigated following the intramuscular injection to rabbits. From the gross and histological examinations, β-CyD was found to alleviate the muscular tissue damage produced by CPZ on M. vastus lateralis in rabbits. The protective effect of β-CyD may be ascribed to the decrease in affinity of CPZ to the tissue membrane through inclusion complexation. The present data suggest that β-CyD complexation is particularly useful to reduce the local toxicity of phenothiazine neuroleptics without altering the pharmacological efficacy.
关键词：gross and histological examinations