文章基本信息

标题：CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A1, A2 AND B2)
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作者：KINZO MATSUMOTO ; KEN-ICHI SAITO ; HIDEOMI FUKUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：10
页码：784-786
DOI：10.1248/bpb1978.6.784
出版社：The Pharmaceutical Society of Japan
摘要：Prostaglandins A₁, A₂ and B₂ (PG A₁, A₂ and B₂) dose-dependently inhibited specific [³H] diazepam binding to rat brain membranes but did not affect specific [³H]Ro 5-4864 binding to kidney membranes. The inhibition of [³H] diazepam binding to brain membranes by benzodiazepine agonists (diazepam and flurazepam) was potentiated by 30 μM GABA, whereas those of prostaglandins were not modified by the same concentration of GABA. These results suggest that PG A₁, A₂ and B₂ specifically interact with central type-benzodiazepine receptors in a manner different from interactions seen with benzodiazepine agonists.
关键词：kidney