文章基本信息

标题：BIOCHEMICAL INVESTIGATION ON THE ABNORMAL BEHAVIORS INDUCED BY FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN TO MICE
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作者：MIKIO YAMAZAKI ; SHIGETOSHI SUZUKI ; NAOKO OZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：10
页码：748-751
DOI：10.1248/bpb1978.6.748
出版社：The Pharmaceutical Society of Japan
摘要：The relationships between behavioral responses and levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brain of mice were investigated after intravenous injection of fumitremorgin A (FTA). The latent periods to the onset of tremor, clonic convulsion, tonic convulsion and death induced by FTA are observed in a dose-dependent fashion. However, the dose-dependency is not observed between levels of 5-HT and 5-HIAA and activities of 5-HT metabolizing enzymes in brain of FTA-treated mice. Insignificant participation of serotonergic mechanism in modulation of those behavioral states elicited by FTA is conclusively suggested.
关键词：Aspergillus fumigatus