文章基本信息

标题：EFFECT OF CHLORPROMAZINE ON INTESTINAL ABSORPTION OF SULFAMETHOXAZOLE IN RATS
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作者：HEE CHUNG YONG ; RYUICHIRO NISHIGAKI ; TATSUJI IGA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：11
页码：829-835
DOI：10.1248/bpb1978.6.829
出版社：The Pharmaceutical Society of Japan
摘要：The effect of chlorpromazine (CPZ) on the intestinal absorption of sulfamethoxazole (SMZ) was studied in isolated perfused rat small intestine by comparing two determinants, i.e. the epithelial permeability and the intestinal blood flow. The appearance rate of SMZ in blood in the presence of CPZ decreased to one-half of the control without CPZ. The pH of perfusion solution was significantly decreased by CPZ after 10 min perfusion. According to the Winne's absorption model, CPZ did not change the apparent epithelial permeability of SMZ, but decreased the epithelial permeability of unionized SMZ due to the decrease in the pH of perfusion solution by CPZ. It was also suggested that CPZ decreased the fraction of the total blood flow rate in the subepithelial capillaries to less than one-half.
关键词：intestinal blood flow