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标题：GROWTH-INHIBITION OF LEUKEMIA L-1210 ASCITES TUMOR BY COMBINATION OF CARRAGEENAN AND MITOMYCIN C IN VIVO
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作者：TATSUJI MATSUMOTO ; AKIRA TAGUCHI ; YOSHIO OKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1984
卷号：7
期号：7
页码：465-471
DOI：10.1248/bpb1978.7.465
出版社：The Pharmaceutical Society of Japan
摘要：A purified ι-carrageenan prepared by means of pronase digestion and fractional precipitation with KCl was in vestigated for its growth-inhibitory effect on mouse leukemia L-1210 transplanted in (C57BL/6 × DBA/2)F₁ (BDF₁) mice. This carrageenan specimen was not growth-inhibitory on this tumor when it was administered alone in a dose of 0.1 to 10 mg/kg/d, 4 times. However, in combination with a small amount of mitomycin C, 0.25 mg/kg/d, a remarkable tumor growth-inhibition has manifested affording a complete regression of this tumor. Acid phosphatase α-galactosidase and active oxygen generation activities of the peritoneal exudate cells in the carrageenan-administered mice were remarkably higher than those of the control mice. Therefore, the booster effect of this carrageenan preparation on antitumor activity mitomycin C is assumed to be associated with the inflammatory activity of this sulfated polysaccharide.
关键词：antitumor activity