文章基本信息

标题：Prevention of Gastrointestinal Absorption of Phenobarbital by Activated Carbon Beads as an Oral Adsorbent
本地全文：下载
作者：Yoshiteru HONDA ; Masahiro NAKANO ; NaomiI. NAKANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1990
卷号：13
期号：10
页码：597-601
DOI：10.1248/bpb1978.13.597
出版社：The Pharmaceutical Society of Japan
摘要：The in vitro adsorption characteristics of activated carbon beads suitable for oral administration and the original fine powder were examined, using phenobarbital as the test drug. The extent and rate of drug adsorption on carbon in the beads were almost equal to those on the powder. In three healthy volunteers, 10 g of activated carbon beads administered orally 20 min after 120 mg of phenobarbital, reduced the total bioavailability by 57% (p<0.005), based on the salivary AUC-value during 96 h and the achieved peak concentration of the drug in saliva by 51%. These results demonstrated the potency of activated carbon beads as a gastrointestinal adsorbent in acute intoxications from phenobarbital.
关键词：gastrointestinal adsorbent