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标题：EFFECTS OF MORPHINE AND INDOMETHACIN ON EVOKED NEURONAL RESPONSES OF VENTROBASAL THALAMIC NEURONES : SITE OF ACTION OF ANALGESIC DRUGS IN NONADJUVANT ARTHRITIC RATS
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作者：SHIGERU OKUYAMA ; HIRONAKA AIHARA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：1
页码：56-63
DOI：10.1248/bpb1978.8.56
出版社：The Pharmaceutical Society of Japan
摘要：Single neuronal activity was recorded extracellularly in the ventrobasal (VB) nucleus of the thalamus in non-adjuvant arthritic rats under urethane (1200mg/kg, i.p.) anesthesia. The effects of morphine and indomethacin on the evoked responses elicited by noxious stimuli such as transcutaneous electrical stimulation (TES) or tibial nerve electrical stimulation (TNES), or non-noxious stimulation such as repetitive brushing were examined. Intravenous administered morphine (0.1, 0.3 and 1mg/kg) depressed the evoked responses elicited by either TES or TNES without affecting any background activities. In contrast, intravenous administered indomethacin (1, 3 and 10mg/kg) depressed the evoked responses induced by TES, but failed to depress the evoked responses induced by TNES. At doses of 3 and 10mg/kg, indomethacin slightly depressed the background activities of the nociceptive neurones. Depressant effects of morphine were restored by intravenous naloxone (0.5 mg/kg) administration, but not observed in case of indomethacin. The evoked responses induced by non-noxious stimulation failed to depress either indomethacin or morphine administration. These results suggest that the site of action of indomethacin in non-adjuvant arthritic rats is mainly in the periphery. In contrast, morphine produced an antinociceptic action due to the central mechanism.
关键词：naloxone