文章基本信息

标题：PROMOTING MECHANISM BY BILE SALT RELATED TO WATER ABSORPTION IN DRUG RECTAL ABSORPTION
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作者：TOYOTO HIRASAWA ; MASAHIRO HAYASHI ; MASAHARU SHIGA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：3
页码：211-216
DOI：10.1248/bpb1978.8.211
出版社：The Pharmaceutical Society of Japan
摘要：The promoting mechanism by bile salts in rat recatal absorption of antipyrine was studied by the in situ recirculating perfusion. The significant correlation between rectal absorption clearance (CL_AP) of antipyrine (AP) and apparent water influx (infulx') was found in the control without promoters, indicating the existence of solvent drag in the AP rectal absorption. Sieving coefficient of AP (b_AP), i.e. the slope of the regression line between CL_AP and influx', was 0.6 approximately equal to that in small intestine reported previously. The relation between the promoting effects and solvent drag was further studied, resulting that both CL_AP and influx'were significantly enhanced by sodium taurocholate (TC-Na), sodium glycocholate (GC-Na) and sodium cholate (C-Na). Accordingly the promoting effects of bile salts might be due to the increase in solvent drag. However TC-Na did not produce the significant change in b_AP. From these results, the enhancing mechanism in the epithelial cell membrane transport was discussed.
关键词：sodium taurocholate