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标题：EVALUATION OF THE BOLIE MODEL DESCRIBING BLOOD GLUCOSE RESPONSE FOR THE APPLICATION TO CONTINUOUS SUBCUTANEOUS INSULIN INFUSION
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作者：HIROKI HIRAYAMA ; YASUJI KASUYA ; AKIRA YAGISHITA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：10
页码：808-818
DOI：10.1248/bpb1978.8.808
出版社：The Pharmaceutical Society of Japan
摘要：In an attempt to develop an appropriate infusion program in a continuous subcutaneous insulin infusion system, a conventional pharmacodynamic model (the Bolie model) for describing the relationship between blood glucose and serum insulin levels was evaluated, using a depancreatized dog preparation. The Bolie model was found useful in estimating the basal insulin infusion rate. However, the model could not predict the serum insulin concentration-time profile required to maintain the postprandial blood glucose levels within a physiological range. It will be necessary to develop a more appropriate model for determining the prandial subcutaneous insulin infusion rates in the continuous subcutaneous insulin infusion system.