文章基本信息

标题：EFFECTS OF PROPRANOLOL ON INFARCT SIZE AND THE IMPAIRED HEMODYNAMICS IN EXPERIMENTAL MYOCARDIAL INFARCTED DOGS
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作者：KATSUHARU TSUCHIDA ; RYUZABURO YAMAZAKI ; KATSUYOSHI KANEKO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：11
页码：964-968
DOI：10.1248/bpb1978.8.964
出版社：The Pharmaceutical Society of Japan
摘要：We studied the effects of propranolol on infarct size and hemodynamic impairment induced by 24 h-coronary ligation. The myocardial infarction produced by the left circumflex coronary artery ligation was more consistent than that induced by the left anterior descending coronary artery ligation, suggesting that the former is a more appropriate experimental model for pharmacological evaluations. Oral treatment with propranolol, 3-30 mg/kg, reduced infarct size and reduced the elevated left ventricular end-diastolic pressure, which was shown to be most closely related with infarct size, in dogs with circumflex coronary artery ligation extending over 24 h. In conclusion, our results indicate that propranolol protects against the enlargement of infarct size and improves the impaired hemodynamics observed in myocardial infarcted dogs with occlusions extending over 24 h, as well as in dogs with less than 24 h-occlusions reported by numerous investigators.
关键词：hemodynamics