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标题：PROTECTIVE EFFECT OF ACIDIC MANNAN FRACTION OF BAKERS' YEAST AGAINST STAPHYLOCOCCUS AUREUS INFECTION IN MICE
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作者：YOSHIO OKAWA ; YASUSHI OKURA ; KAZUHIKO HASHIMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：11
页码：942-947
DOI：10.1248/bpb1978.8.942
出版社：The Pharmaceutical Society of Japan
摘要：Protective activity of an acidic fraction of bakers' yeast mannan containing protein and phosphorus, designated as WAM025, against infection of Staphylococcus aureus βH 248 strain in mice was investigated. WAM025 elicited a marked increase in the survival ration of mice challenged with viable cells of the S.aureus strain, 5×10⁸ cells per mouse, when the fraction was administered to mice 150 mg/kg/d, 5 times, intraperitoneallyl. The effect was stronger than that of WNM, a neutral fraction of mannan obtained from the same bakers' yeast. The difference seemed to correlate with the strength of activating effects of WAM025 and WNM on the reticuloendotherial system of the host animal. WAM025 induced higher activities of serum lysozyme and carbon clearance in mice than WNM. Also, mice treated with WAM025 showed a greater increase in number and activity of oxygengenerating blood polymorphonuclear leucocytes than mice treated with WNM.
关键词：chemiluminescence