文章基本信息

标题：STRUCTURE-ACTIVITY RELATIONSHIP OF BUFOTOXINS AND RELATED COMPOUNDS FOR THE INHIBITION OF Na+, K+-ADENOSINE TRIPHOSPHATASE
本地全文：下载
作者：KAZUTAKE SHIMADA ; KAZUO OHISHI ; HIROKO FUKUNAGA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：12
页码：1054-1059
DOI：10.1248/bpb1978.8.1054
出版社：The Pharmaceutical Society of Japan
摘要：Forty kinds of bufotoxins and related compounds were tested for inhibition of Na⁺, K⁺-adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The inhibitory activities of bufotoxins were dependent upon the dicarboxylic acid and amino acid components. The compounds having both the arginine and suberic acid moieties showed the higher inhibitory activities. The sulfates and glucuronides of cardiac steroids exhibited much less potency than the parent genins. The mode of inhibition was determined by means of the Dixon and Lineweaver-Burk plots.
关键词：structure-activity relationship