文章基本信息

标题：ENHANCED RECTAL ABSORPTION OF β-LACTAM ANTIBIOTICS IN RAT BY MONODESMOSIDES ISOLATED FROM PERICARPS OF SAPINDUS MUKUROSSI (ENMEI-HI)
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作者：NOBORU YATA ; NARUMI SUGIHARA ; RYOKO YAMAJO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：12
页码：1041-1047
DOI：10.1248/bpb1978.8.1041
出版社：The Pharmaceutical Society of Japan
摘要：Monodesmosides, saponin A, B and C, isolated from pericarps of Sapindus mukurossi(Enmei-hi) were shown to promote the rectal absorption of β-lactam antibiotics in rat, using an in situ loop method and an in vivo method. In the in situ loop method, monodesmosides were solubilized with a mixture of bisdesmosides, mukurozi-saponin X, Y₁ and Y₂, each of which was isolated from pericarps of Sapindus mukurossi. The promoting functions of the three monodesmosides for the rectal absorption of antibiotics were comparable and also suppressed by Ca²⁺ ion coexisting in the administered solution. Unlike the case of N-acylcollagenpeptides, which were also previously reported as absorption promoters, no influence of osmolarity of the administered solution on the absorption promoting action was observed. Absorption of β-lactam antibiotics from suppositories was enhanced with the aid of either of monodesmosides without solubilizing agent.