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标题：INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
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作者：CHIAKI KAMEI ; HIROMICHI AKAHORI ; KENJI TASAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1986
卷号：9
期号：1
页码：112-116
DOI：10.1248/bpb1978.9.112
出版社：The Pharmaceutical Society of Japan
摘要：Intraventricular injection of histamine (Hi) significantly prolonged thiopental sleeping time at doses of 0.5μg or larger. Both 1-methylHi and imidazole-4-acetic acid, howere, did not affect thiopental narcosis. Pretreatment with α-fluoromethylhistidine diminished the effect of Hi, while histidine, metoprine and quinacrine prolonged thiopental narcosis. Injection with 2-methylHi did not affect thiopental sleeping time, while as in the case of Hi, 4-methylHi augmented the thiopental effect. In addition, H₂-receptor blocking agents such as cimetidine, ranitidine and famotidine clearly antagonized Hi-induced prolongation of thiopental narcosis, while pyrilamine and chlorpheniramine had no effect. These results indicate that Hi-induced prolongation of thiopental narcosis appears to be exerted via H₂ receptors and is, in some way, related to the Hi content in the brain.
关键词：aminoguanidine