文章基本信息

标题：TUMOR ACCUMULATION OF D-SELENOMETHIONINE-75Se IN TUMOR-BEARING MICE
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作者：RENSUKE GOTO ; KEIKO UNNO ; ATSUSHI TAKEDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：9
页码：456-461
DOI：10.1248/bpb1978.10.456
出版社：The Pharmaceutical Society of Japan
摘要：The radioactivity distribution of ⁷⁵Se-labeled D-selenomethionine (D-SeMet-⁷⁵Se) was investigated in tumor-bearing mice in order to develop a new radioactive diagnostic agent. D-SeMet-⁷⁵Se was enzymatically prepared from commercially available L-selenomethionine-⁷⁵Se (L-SeMet-⁷⁵Se) by using amino acid reacemase and immobilized L-amino acid oxidase. No difference between D- and L-SeMet-⁷⁵Se was found in the excretion rate into urine and feces in normal mice within 48 h after administration. The in vivo uptake of D-SeMet-⁷⁵Se in both Ehrlich solid tumor and sarcoma- 180 solid tumor was several times higher than that of L-SeMet-⁷⁵Se but the uptake of D- and L-SeMet- ⁷⁵Se were similar in the pancreas. These results indicated that D-SeMet-⁷⁵Se might be useful as a tumor-imaging agent. In vitro experiments on Ehrlich ascites tumor cells showed that D-SeMet-⁷⁵Se was incorporated into the tumor cells by a Na⁺-dependent active transport system similar to L-SeMet-⁷⁵Se and that a transport mechanism specific for D-SeMet-⁷⁵Se might be present in tumor cells in addition to a transport system common to both D- and L-forms.
关键词：tumor-imaging agent