文章基本信息

标题：INHIBITION OF SUPEROXIDE ANION PRODUCTION IN GUINEA PIG POLYMORPHONUCLEAR LEUKOCYTES BY A SELENO-OR-GANIC COMPOUND, EBSELEN
本地全文：下载
作者：SHIGEMI ICHIKAWA ; KAZUE OMURA ; TERUAKI KATAYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：10
页码：595-597
DOI：10.1248/bpb1978.10.595
出版社：The Pharmaceutical Society of Japan
摘要：Production of superoxide anion (O^-₂) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O^-₂ production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.
关键词：glutathione metabolism