文章基本信息

标题：POSSIBLE MECHANISM INVOLVED IN THE INHIBITORY ACTION OF U-50, 488H, AN OPIOID κ AGONIST, ON GUINEA PIG HIPPOCAMPAL CA3 PYRAMIDAL NEURONS IN VITRO
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作者：TOSHI IWAMA ; KUMATOSHI ISHIHARA ; HIROSHI TAKAGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：10
页码：564-570
DOI：10.1248/bpb1978.10.564
出版社：The Pharmaceutical Society of Japan
摘要：Intracellular recordings of the CA3 pyramidal neurons in the guinea pig hippocampus were made in vitro. U-50 488H (100 μM), a selective opioid κ agonist, decreased the synaptic response produced by stimulation of the mossy fibers but did not affect the membrane potential, the input resistance and the generation of the Na⁺ spikes or the Ca²⁺ spikes. Iontophoretically applied U-50 488H depressed the depolarization produced by L-glutamate. U-50 488H (100 μM) also depressed the consistent depolarization produced by veratrine (3×10^-5 g/ml) and this effect was partially antagonized by naloxone. Moreover, application of U-50 488H led to a disappearance of the anomalous rectification. These results suggest that U-50 488H depresses the synaptic activities of the CA3 pyramidal neurons by inhibiting a subtype of the Na⁺ channel, "Na⁺ channel type II"which slowly closes, of the soma and/or the dendrites of the neurons.
关键词：guinea pig