文章基本信息

标题：A Pharmacokinetic Model for Percutaneous Absorption of Valproic Acid and Prediction of Drug Disposition
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作者：Taro OGISO ; Yoshimasa ITO ; Masahiro IWAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1988
卷号：11
期号：6
页码：444-452
DOI：10.1248/bpb1978.11.444
出版社：The Pharmaceutical Society of Japan
摘要：To predict the plasma concentrations after percutaneous application of valproic acid (VPA), we presented a new pharmacokinetic model which includes simultaneous two absorption processes through the skin. The simulation contains four first-order rate constants for the following : a) absorption via the lipid and water routes in skin and b) uptake from the skin into systemic circulation and subsequent elimination. The fitness of the model presented for experimental data was compared with simple one-compartment models. As a result, the new model was successfully able to describe the time course of the plasma VPA concentrations following percutaneous application of the ointments. VPA was found to be rapidly absorbed across the water routes (k_al=2.60 h^-1), which accounted for about 70% of the total, followed by a lasting absorption via the lipid routes (k_a2=0.108 h^-1). The pharmacokinetic model with parallel lipid and aqueous pore skin transport pathways in skin was more adequate for the interpretation of p.c. absorption data of VPA than the models with an absorption process.
关键词：ointment