文章基本信息

标题：Intestinal Absorption Kinetics Using a Laminar Flow Model
本地全文：下载
作者：Masahiro YOKOKAWA ; Ryuichiro NISHIGAKI ; Koshiro UMEMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1989
卷号：12
期号：6
页码：332-340
DOI：10.1248/bpb1978.12.332
出版社：The Pharmaceutical Society of Japan
摘要：The drug concentration profile at non-steady state in the intestine was simulated using a laminar flow model. The transport equation with cylindrical coordinates was solved by a finite difference method to simulate the concentration profile in the tube and the exit cup-mixing concentration. A drug with a various wall permeability coefficient (P_w=zero or 10^-5 to 10^-3 cm/s) and diffusion constant (D=10^-6 to 10^-4 cm²/s) was assumed to be introduced into the tube in a pulse form. The spatial intervals of the grid and the time step were varied to yield the optimum condition for calculation. The concentration profile in the tube as the time elapsing and the exit cup-mixing concentration versus time profile were shown graphically. P_w and D influenced the concentration profiles. This suggests the possibility of the estimation of P_w and D by determining the exit cup-mixing concentration after a pulse input to a perfused intestine under a laminar flow condition.
关键词：finite difference