文章基本信息

标题：Increased Production and/or Secretion of Pulmonary Surfactant in Rats by Long Term Sulfur Dioxide Exposure
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作者：Yoshiaki ODA ; Yoichiro ISOHAMA ; Hirofumi KAI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1989
卷号：12
期号：12
页码：726-730
DOI：10.1248/bpb1978.12.726
出版社：The Pharmaceutical Society of Japan
摘要：Influence of long term SO₂ exposure on the pulmonary surfactant in rats was studied by means of chemical analysis and microscopic verification. At a time after termination of the exposure period, the general symptom in rats was similar to that of bronchitis. The content of disaturated phosphatidylcholine, a main functional component of the pulmonary surfactant, significantly increased not only in broncho-alveolar lavage fluid but also in pulmonary microsomal fraction by long term SO₂ exposure. Microscopic verification of alveolar type II cells from the bronchitic rats demonstrated the development of rough surface endoplasmic reticulums and an increase of the number of osmiophillic bodies. The results suggest that pulmonary surfactant production and/or secretion are activated in rats with bronchitis caused by long term SO₂ exposure.
关键词：broncho-alveolar lavage fluid