文章基本信息

标题：SYNTHESIS OF VALPROYL-2-PYRROLIDINONE AND ITS EVALUATION AS A COGNITIVE DRUG WITH THE ABILITY TO MODULATE ACIDIC AMINO ACIDS IN THE BRAIN
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作者：Choichiro MIYAZAKI ; Kenji MATSUYAMA ; Masataka ICHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1990
卷号：13
期号：1
页码：70-75
DOI：10.1248/bpb1978.13.70
出版社：The Pharmaceutical Society of Japan
摘要：A new pyrrolidinone derivative, valproyl-2-pyrrolidinone (VP), was synthesized, followed by evaluation as a cognitive drug. VP gave rise to a significant protective effect against cerebral anoxia together with a potent prolongation of latency time for the reversal of scopolamine induced transient disruption of the memory of a passive avoidance response in rats. The quantitative experiment using HPLC demonstrated a significant reduction of hippocampal aspartate (Asp) and glutamate (Glu) following the intraperitoneal administration of VP at a dose of 300 mg/kg.
关键词：acidic amino acid