文章基本信息

标题：Pharmacokinetics of Cefpiramide in Rats Acutely Intoxicated with Carbon Tetrachloride
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作者：Chu LI ; Seiya NAKAYAMA ; Yuji KUROSAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1990
卷号：13
期号：3
页码：186-194
DOI：10.1248/bpb1978.13.186
出版社：The Pharmaceutical Society of Japan
摘要：Pharmacokinetics of cefpiramide (CPM) were investigated in normal rats and rats with hepatic intoxication induced by a single oral administration of carbon tetrachloride (CCl₄). The elimination half-life of the antibiotic was prolonged in CCl₄-intoxicated rats and the total body clearance in CCl₄-intoxicated rats (153.9 ml/h/kg) was about 40% of the control value (390.3 ml/h/kg), while the volume of distribution for CPM was scarcely affected. The hepatic clearance of CPM was markedly diminished and the renal clearance of CPM was slightly, but not significantly, decreased in CCl₄-intoxicated rats. It seems that the hepatic clearance of CPM was decreased owing to at least two factors ; (1) decrease in CPM uptake by hepatocytes and (2) decrease in bile flow, while the renal clearance of CPM was slightly decreased owing to decrease in the renal tubular secretion. These results suggest that CCl₄ intoxicates not only the liver but also the kidney to a small extent.
关键词：pharmacokinetics