文章基本信息

标题：EXPERIMENTAL STUDIES ON n-BUTYLPYRROLIDINE POISONING
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作者：Hiroshi YOSHIKAWA ; Kiyoyuki KAWAI
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1966
卷号：4
期号：3
页码：63-68
DOI：10.2486/indhealth.4.63
出版社：National Institute of Occupational Safety and Health
摘要：In a factory a worker died shortly after he received an accidental pour of the n -butylpyrrolidine over his upper trunk. In this connection animal experiments were undertaken to obtain some information on toxic properties of this substance. Intraperitoneal, subcutaneous and oral LD₅₀ values of n -butylpyrrolidine in mice were 37. 3, 56.8 and 51.1 mg/kg respectively. In this respect n -butylpyrrolidine should be regarded as a highly toxic substance. Outstanding feature of this acute poisoning in mice was immediate onset of clonic convulsion with a fatal outcome in several minutes. Once the attack was overcome, the mice showed rapid recovery. Application of n -butylpyrrolidine on sheared skin also revealed its lethal toxicity without any local injury. The LD₅₀ in the skin test was about 1.0 ml/kg and rapid absorption from intact skin was suggested. Daily administration of n -butylpyrrolidine, even at the dose of 20 mg/kg, were tolerated in mice at least until 4 weeks without any evidence of abnormality.